SAINT-EUSTACHE, Quebec--(BUSINESS WIRE)--#GrowthList--Canadian Business ranked HGregoire 131st out of 415 on its prestigious annual Growth List of Canada's Fastest-Growing Companies. HGregoire earned the distinction in part due to its impressive five-year revenue growth of 701%.
“Receiving this level of recognition is very special for us,” says John Hairabedian, president of HGregoire. “We’ve set out to redefine the car buying experience and, at moments like these, we can really take a step back and come to terms with the progress we’ve made for ourselves, our industry but, most importantly, in the life of our customer.”
Produced by Canadian Business and Maclean’s, Canada’s premier business and current affairs media brands, the Growth List ranks Canadian businesses on five-year revenue growth.
“The companies on the 2020 Growth List are really exceptional,” says Susan Grimbly, Growth List Editor. “As we celebrate over 30 years of the Canada’s Fastest-Growing Companies program, it’s encouraging to see that the heart of Canada’s entrepreneurial community beats strong, even in tough times.”
An industry leader in Quebec and Florida through the HGregoire, HGreg.com and HGreg Lux brands, HGregoire is comprised of more than 1,500 passionate associates committed to redefining the car buying experience. Founded in 1993, the company has grown to 21 new and pre-owned dealerships in Canada and 8 in the United States. For more information about the company and its unique history, visit hgregoire.com.
About the Growth List
For over 30 years, the Growth List ranking of Canada’s Fastest-Growing Companies (formerly the Growth 500) has been Canada’s most respected and influential ranking of entrepreneurial achievement. Originally developed by PROFIT and now published in a special Growth List print issue of Canadian Business (packaged with the December issue of Maclean’s magazine) and online at GrowthList.ca and CanadianBusiness.com, the Growth List ranks Canadian companies on five-year revenue growth, and the Startup List ranks Canadian new growth companies on two-year revenue growth. For more information on the ranking, visit GrowthList.ca.
About Canadian Business
Founded in 1928, Canadian Business is the longest-serving business publication in the country. It has fuelled the success of Canada’s business elite and, through the Growth List ranking, celebrates leadership, innovation, business strategy and management tactics. Learn more at CanadianBusiness.com.
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Iconic fashion designer Hayley Elsaesser – the granddaughter of a newspaper owner – launches limited-edition ‘Champion the Truth’ capsule collection in celebration of Canadian news media
TORONTO--(BUSINESS WIRE)--#ChampionTheTruth--Yesterday marked the official start of the 80th National Newspaper Week, an annual opportunity for Canadians to celebrate and reflect on the essential service provided by the news media industry in this country.
“Now, more than ever, Canadians are turning to newspapers as a trusted source of information, because they know they can count on them for credible, fact-based news reporting,” said Bob Cox, Publisher of the Winnipeg Free Press and Chair of News Media Canada, the association that represents the Canadian news media industry. “An active and healthy democracy relies on an active and healthy news media. While we champion the work of Canadian newspapers all year long, this week provides a unique opportunity to recognize, celebrate and support our newspapers and the people behind them.”
In celebration of this year’s event, headline-grabbing fashion designer Hayley Elsaesser has partnered with News Media Canada to launch a limited-edition ‘Champion the Truth’ capsule collection. This unique collection includes a t-shirt, tote bag and mask, each emblazoned with the words “news” and “truth”, in various languages, alongside Elsaesser’s iconic mouthy print design. Elsaesser’s design was inspired by the role that newspapers play in supporting local communities – a connection that’s deeply personal to the designer.
“My grandfather was the owner and publisher of a local newspaper in British Columbia, so I’ve seen first-hand the impact a strong and thriving newspaper can have on the community in which it operates,” Elsaesser explained. “I’m a fierce supporter of a vibrant free press, and I hope this collection helps celebrate the important role newspapers play in keeping communities connected from coast-to-coast-to-coast.”
Newspaper readers across the country can now show their support for the industry by purchasing an item from Hayley’s Champion the Truth collection available at hayleyelsaesser.com. All proceeds from the sales of the Champion the Truth capsule collection will be donated to Canadian Journalists for Free Expression (CJFE) in support of Canadian journalism.
“We know that nine in 10 Canadians are reading newspaper content in print or online every week,” concluded Cox. “This National Newspaper Week, we have a unique opportunity to show our support and appreciation to our local news media who have been committed to serving their readers, to publishing the truth, and to performing an essential public service providing credible, reliable journalism Canadians have come to rely on.”
A print and digital ad campaign that celebrates National Newspaper Week will also run in local, regional and national newspapers across Canada.
National Newspaper Week concludes this Saturday, October 10, 2020. This project has been made possible in part by the Government of Canada.
About News Media Canada
News Media Canada is the voice of the print and digital news media industry in Canada and represents hundreds of trusted titles in every province and territory. News Media Canada is an advocate in public policy for daily and community media outlets and contributes to the ongoing evolution of the news media industry by raising awareness and promoting the benefits of news media across all platforms. For more information, visit www.newsmediacanada.ca or follow us on Facebook, Twitter, Instagram and YouTube.
Bronte Wright, Craft Public Relations
CALGARY, Alberta--(BUSINESS WIRE)--Blackline Safety Corp. (TSX.V: BLN), a global leader of gas detection and cloud-connected safety solutions, has been recognized by Fast Company in the 2020 Innovation by Design Awards for its Industrial Contact Tracing solutions released earlier this year. This new capability enables Blackline’s portfolio of G7 connected safety and gas detection solutions to help businesses identify locations where workers regularly come into close contact and compile a list of Blackline device users that an individual may have interacted with. Blackline’s Industrial Contact Tracing solutions were acknowledged in the Data Design category based on interactive data-driven analytics reports that helps investigators trace potential points of contact and where they occurred through a series of data visualizations.
“We need innovative design more than ever, and the 2020 honorees have brought creativity, inventiveness, and humanity to address some of the world’s most pressing problems, including the global pandemic, racial injustice, and economic inequality. Together these entries offer a glimpse into a future that is more inclusive, more accessible, and more just,” said Stephanie Mehta, editor-in-chief of Fast Company.
“As we face new and unforeseen challenges, including COVID-19, it becomes critical to leverage all of the data at our disposal to keep workers protected, and support the production and delivery of essential goods and services,” said Cody Slater, CEO and Chairman at Blackline Safety. “Together, connected technology and data empowers decision-making and improves worker safety — this is the future of the industrial workforce. To be recognized by Fast Company in the 2020 Innovation by Design Awards is a testament to the innovation and dedication our people bring to work each day to fulfill our purpose of ensuring that every worker remains healthy at work and returns home safely.”
During the ongoing COVID-19 global pandemic, Blackline Safety is helping companies to create a flexible contact tracing program and ensure a safe environment for all employees returning to work. Blackline’s Industrial Contact Tracing solutions leverage data streamed by location-enabled G7 safety wearables and compiles this data into a series of reports that are available to clients through its cloud-based Blackline Analytics portal. This data drives interactive contact tracing reports that can immediately retrace workers’ steps to see who he or she may have had contact with should they present with symptoms or test positive for COVID-19. These solutions fill the contact-tracing gap left by smartphones and mobile apps that lack intrinsic safety certification and cannot be deployed for hazardous or industrial applications.
Fast Company’s Innovation by Design Awards, now in its ninth year, recognizes people, teams and companies working to solve the problems of today and tomorrow through innovative design. Honorees are determined by a panel of renowned designers from a variety of disciplines, business leaders from around the world and Fast Company’s own writers and editors. Blackline Safety’s Industrial Contact Tracing solutions will be featured online and in the October / November issue of Fast Company’s print magazine, available on newsstands October 20.
In addition to receiving recognition from Fast Company, Blackline’s Industrial Contact Tracing solutions were recently recognized by Occupation Health & Safety (OH&S) Magazine in the 2020 New Product of The Year awards. To learn more about these solutions, visit www.blacklinesafety.com/contact-tracing.
About Blackline Safety: Blackline Safety is a global connected safety leader that helps to ensure every worker gets their job done and returns home safe each day. Blackline provides wearable safety technology, personal and area gas monitoring, cloud-connected software and data analytics to meet demanding safety challenges and increase productivity of organizations in more than 100 countries. Blackline Safety wearables provide a lifeline to tens of thousands of men and women, having reported over 100 billion data-points and initiated over five million emergency responses. Armed with cellular and satellite connectivity, we ensure that help is never too far away. For more information, visit BlacklineSafety.com and connect with us on Facebook, Twitter, LinkedIn and Instagram.
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
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NEW YORK--(BUSINESS WIRE)--#identityresolution--The global Customer Intelligence Platform Zeotap, announced today that ID+, its universal marketing identity solution launched in July 2020, is now available as a module of Prebid, the most widely used header bidding platform for publishers. Launched in 2015, the Prebid project is led by a neutral industry organization that makes header bidding easier for publishers by bringing conformity and simplicity to the process. The inclusion of ID+ in Prebid’s User ID module ensures ID+ can be transacted across the ecosystem.
In just two months, Zeotap’s ID+ initiative has been endorsed by more than 25 leading players across the ecosystem. The latest adopters include Amnet, Publicis, HOLA, Unidad Editorial, and Contversion.
Digital Identity at Risk
Digital identity has been universally challenged since 2017, but it wasn’t until 2020 when the whole adtech and martech ecosystem found itself at a turning point. Third-party cookies on Safari have already been blocked since 2019 as a result of Apple’s effort to strengthen consumer privacy. Google will be joining Apple in this endeavor and will be implementing the same measures for Chrome by 2022. In addition, Apple is also moving to IDFAs (Identifier For Advertisers), a random device identifier assigned by Apple to a user's device for tracking and customer advertising, to opt-in only — largely limiting in-app targeting and measurement capabilities.
Declining CPMs Plague Publishers
Publishers are already experiencing media CPM drops because Safari comprises 53% of their mobile traffic in the US and less than 10% of those users allow 3rd party cookies. According to a recent study, CPMs on Safari fell by over 60% since Intelligent Tracking Protection (ITP) became effective in 2017. The imminent blocking of 3rd party cookies in Chrome and the upcoming changes as it pertains to IDFA will accelerate the decline of media CPMs even further.
Zeotap’s ID+ Initiative
Zeotap founded its universal ID marketing initiative, ID+, to enable the future of identity in an identifier-agnostic environment and solve the pressing problem of CPM declines.
Daniel Heer, CEO and CO-Founder of Zeotap said, “Zeotap’s ID+ initiative was conceived on four core tenets: independence, simplicity, interoperability, and compliance. We are inviting the entire ecosystem to collaboratively solve the industry challenge of attaining accurate digital identities across devices.”
Becoming part of the ID+ ecosystem is as easy as integrating a website pixel. Users visiting a publisher’s site are stamped with a unique ID+ identifier that enables programmatic transactions moving forward. When a user browses through a website, zeotap creates an ID+ cookie (in a first-party context) that is unique to a browser, website, and device. This ID+ identifies each user at a non-PII individual level and attaches all the information that is additionally collected, including the deterministic identities in case they have used a login. The ID+ cookie, however, is created whether or not the user logs in — provided there is user consent.
Currently, zeotap is also making 3rd party cookie syncing available until they disappear entirely, giving publishers the option to select who they want to cookie sync with from an extensive list of zeotap’s integrated partners. This makes publishers future-ready, without requiring them to make any changes when transitioning from 3rd party cookies to ID+ in the future.
Industry Testimonials for ID+
"We are currently monitoring all solutions that will work in the cookieless future and find Zeotap's ID+ approach, as a neutral provider, very exciting and promising. We are very much looking forward to cooperating with them." - Giorgi Khutsishvili, Director Data Strategy Publicis Media Germany
‘’With the third-party cookie deprecation in the offing, it’s time for the digital ecosystem to ‘’Pause, Reflect and Prepare’’. Privacy and transparency issues have forced all of us to innovate (Focus on Zero Party Data has increased) with customer centricity as the fulcrum. A Single View of the Consumer’ or SVOC has assumed a new dimension and ID resolution is one such initiative that is being undertaken by some partners. I must say Zeotap with its ID+ project is poised to reap early mover advantages while addressing the concerns of all parties involved and also help advertisers prepare for the cookieless future in a more confident manner.’’ - Anil Pandit, Senior Vice President – Programmatic, Publicis Media India
“With third-party cookies continuing to decline and consumer privacy becoming increasingly paramount, this evolution has presented us with an opportunity for data transformation. Zeotap’s ID+ solution is one step forward towards filling the gap created by recent policy changes. Amnet’s partnership with Zeotap is in accordance with our core idea to develop growth and trust in the digital ecosystem.” Salil Shanker, COO Amnet India
About zeotap and ID+
ID+ is a universal digital marketing solution aiming to resolve identities at scale in the nearing cookieless future dominated by privacy regulations. The project is an open invitation to the whole ecosystem to collaboratively solve a pressing industry challenge.
Powered by Customer Intelligence Platform zeotap and its existing patented identity resolution solution, ID+ is built on the back of the world’s largest marketing identity graph, available across North America, Latin America, Europe, and India. The graph, with a strong backbone of emails and MAIDs (Mobile Ad IDs), today counts with over 400M ID-verified/self-declared linkages coupled with unified and curated 3rd party profile data.
ID+ currently counts 25+ partners from global ones such as Amnet, Publicis, OMD EMEA, Annalect, and Accenture, to regional ones such as International Business Time (IBT), PubMatic, Mediasmart, Tabmo, s4m, ItaliaOnline, Imágen Digital, HOLA, Unidad Editorial, Contversion and growing.
Mariona Prat Vila
Global Director Marketing at Zeotap
COLLINGWOOD, Ontario--(BUSINESS WIRE)--#ChooseChickapea--Chickapea is pleased to announce it placed No. 70 on the 2020 Report on Business ranking of Canada’s Top Growing Companies.
Canada’s Top Growing Companies ranks Canadian companies on three-year revenue growth. Chickapea earned its spot with three-year growth of 744%.
"To be included on this list with so many incredible businesses is an honour," says Chickapea Founder and CEO, Shelby Taylor. "Our phenomenal growth is thanks to the increasing number of people that are not only making their health a priority, but choosing to put their hard-earned dollars towards products and businesses that do good in the world. This is a shift I am incredibly proud to be a part of."
Established in 2015 as a healthy alternative to a family staple (pasta), Chickapea has become a leader in the growing high-protein pasta category. Chickapea pasta is made with simple, organic ingredients—only chickpeas and lentils—and available in six varieties in more than 3500 stores across North America.
Chickapea, a Certified B Corporation and Women-Owned Business, ranks in the top 10% of all B Corporations worldwide with a commitment to donate at least 2% of revenue to charity each year. The young company has given $135,000 to feed nutritious meals to children in need and has donated more than 30,000 pounds of Chickapea pasta to food banks and community food centres.
Launched in 2019, the Canada’s Top Growing Companies editorial ranking aims to celebrate entrepreneurial achievement in Canada by identifying and amplifying the success of growth-minded, independent businesses in Canada. It is a voluntary program; companies had to complete an in-depth application process in order to qualify. In total, 400 companies earned a spot on this year’s ranking. The full list of 2020 winners, and accompanying editorial coverage, is published in the October issue of Report on Business magazine—out now—and online at tgam.ca/TopGrowing.
“The stories of Canada’s Top Growing Companies are worth telling at any time, but are especially relevant in the wake of COVID-19 pandemic,” says James Cowan, Editor of Report on Business magazine. “As businesses work to rebuild the economy, their resilience and innovation make for essential reading.”
“Any business leader seeking inspiration should look no further than the 400 businesses on this year’s Report on Business ranking of Canada’s Top Growing Companies,” says Phillip Crawley, Publisher and CEO of The Globe and Mail. “Their growth helps to make Canada a better place, and we are proud to bring their stories to our readers.”
Chickapea’s mission is to create good for the world through nutritious, organic meal options and impactful social contributions. Founded by Shelby Taylor in 2015, Chickapea turned a family favorite (pasta) into a superfood by producing it with only wholesome ingredients: organic chickpeas and lentils. Chickapea’s high-protein pastas are available in more than 3500 stores across North America. All products are certified Vegan, Organic, Gluten-Free, Kosher and Non-GMO. Chickapea is a Certified Women-Owned Business and B Corporation, which meets the highest standards of social and environmental responsibility, accountability and transparency.
About The Globe and Mail
The Globe and Mail is Canada’s foremost news media company, leading the national discussion and causing policy change through brave and independent journalism since 1844. With award-winning coverage of business, politics and national affairs, The Globe and Mail newspaper reaches 5.9 million readers every week in print or digital formats, and Report on Business magazine reaches 2.1 million readers in print and digital every issue. The Globe and Mail’s investment in innovative data science means that as the world continues to change, so does The Globe. The Globe and Mail is owned by Woodbridge, the investment arm of the Thomson family.
Chickapea Media Contact:
New Season Starts Streaming October 30 on Disney+
Discover a Bounty of All-New Star Wars Products, Books, Comics and Digital Content Inspired by the Hit Lucasfilm Series
Pre-Orders on Select Items Begin Later Today
GLENDALE, Calif.--(BUSINESS WIRE)--Fans of the Disney+ original series “The Mandalorian” just received a new reason to look forward to Mondays. Disney and Lucasfilm today announced Mando Mondays, an all-new global consumer products, games and publishing program, kicking off on October 26, that will debut goods inspired by the series.
After premiering last fall and quickly taking the world by storm, “The Mandalorian” – which took home seven awards last week during the 2020 Primetime Emmy® Awards – will return for its highly anticipated second season Friday, October 30, streaming only on Disney+. The Mandalorian and the Child continue their journey, facing enemies and rallying allies as they make their way through the dangerous galaxy in the tumultuous era after the collapse of the Galactic Empire.
After fans experience the latest episode every Friday on Disney+, they can visit MandoMondays.com each Monday to see what new toys, collectibles, apparel, books, comics, digital content and more will be unveiled. Mando Mondays will run for nine weeks, culminating on December 21.
“When ‘The Mandalorian’ debuted last year on Disney+, the show became an instant phenomenon, with fans of all ages expressing excitement for products related to its iconic characters – particularly the Child,” said Kareem Daniel, president, Disney Consumer Products, Games and Publishing. “This fall, as the world continues to watch the narrative unfold, we will further bring this unique Star Wars story to life through a must-have selection of toys, books, comics, digital content, and more.”
To celebrate this announcement, select pre-orders for the first wave of Mando Mondays products will kick off today at 1:00 p.m. PDT / 4:00 p.m. EDT across top retailers globally, including shopDisney.com. Products available for pre-order today include the Hasbro Black Series Credit Collection, new Funko Pop! bobbleheads, the LEGO® Star Wars The Child construction set and much more, all viewable now at MandoMondays.com.
The countdown starts now! For more details, visit MandoMondays.com and follow the conversation on social using #MandoMondays.
About Disney Consumer Products, Games and Publishing
Disney Consumer Products, Games and Publishing (CPGP) brings the magic of The Walt Disney Company’s brands and franchises—including Disney, Pixar, Marvel, Star Wars, National Geographic, and more—into the daily lives of families and fans around the world through products and experiences across more than 100 retail categories from toys and t-shirts to apps, books, video games, and more. A division of the Disney Parks, Experiences and Products segment, CPGP’s global operations include: the world’s largest licensing business, one of the biggest children’s publishing brands, a leading licensor of interactive games across platforms, Disney store locations globally, and the shopDisney e-commerce platform.
About Lucasfilm Ltd.
Lucasfilm Ltd., a wholly-owned subsidiary of The Walt Disney Company, is a global leader in film, television and digital entertainment. In addition to its feature film and series production, the company's offerings include cutting-edge visual effects and audio post-production, digital animation, immersive storytelling, and the management of the global merchandising activities for its entertainment properties including the legendary STAR WARS and INDIANA JONES franchises. Lucasfilm Ltd. is headquartered in northern California.
Lucasfilm, the Lucasfilm logo, STAR WARS and related properties are trademarks and/or copyrights, in the United States and other countries, of Lucasfilm Ltd. and/or its affiliates. © & TM Lucasfilm Ltd.
Disney+ is the dedicated streaming home for movies and shows from Disney, Pixar, Marvel, Star Wars, National Geographic, and more. As part of Disney’s Direct-to-Consumer and International (DTCI) segment, Disney+ is available on most internet-connected devices and offers commercial-free programming with a variety of original feature-length films, documentaries, live-action and animated series and short-form content. Alongside unprecedented access to Disney’s incredible library of film and television entertainment, the service is also the exclusive streaming home for the latest releases from The Walt Disney Studios. Disney+ is available as part of a bundle offer that gives subscribers access to Disney+, Hulu (ad-supported), and ESPN+. Visit DisneyPlus.com to subscribe and/or learn more about the service.
LEGO and the LEGO logo are trademarks of the LEGO Group. ©2020 The LEGO Group.
Disney Consumer Products, Games and Publishing
NEW YORK--(BUSINESS WIRE)--Insider Intelligence today announces that Steve Dodman is joining the company as senior vice president of sales.
At Insider Intelligence, Dodman will lead the global sales organization, providing strategic guidance, leadership, and direction. As a member of the senior executive team, Dodman will also help to set the company's strategy moving forward and deliver against its ambitious financial and strategic goals.
“We're excited to have Steve join our senior team during this period of significant growth and innovation at Insider Intelligence,” said Barbara Peng, president of the company. “Steve will be a tremendous resource for us as we continue to envision new solutions that address real business challenges faced by the world's largest and most innovative corporations.”
Dodman has over 20 years of sales and sales leadership experience with deep domain expertise in the subscription research, advisory and consulting sectors. He is a data-driven, operationally oriented leader who knows how to scale sales teams and execute go-to-market strategies to cultivate high-growth environments. Dodman most recently served as Chief Sales Officer for Richardson Sales Performance, a global sales performance improvement company.
Said Dodman about his new position: "I'm thrilled to join the talented team at Insider Intelligence. The acceleration of digital transformation offers outstanding opportunities for companies to innovate, drive top-line growth, and improve profitability. Insider Intelligence is a powerful resource that provides business leaders with the data and insights needed to make crisp decisions and seize on the promise of the digital decade that lies ahead."
Dodman will report to Peng, and be based at the company’s global headquarters in New York City.
About Insider Intelligence
Formed in 2020 from the combination of eMarketer and Business Insider Intelligence (BII), Insider Intelligence aims to be the world’s leading research service focused on digital transformation. Insider Intelligence helps thousands of global industry leaders to understand the critical trends and developments that are rapidly transforming their industries. Each year, Insider Intelligence produces nearly 300 reports, 7,000 charts, 1,500 newsletters, and 200 forecasts across the Advertising & Marketing, Consumer Demographics, Social Media, Video, Mobile, E-Commerce & Retail, Telecoms & Technology, Financial Services, and Digital Health industries. Insider Intelligence is owned by Berlin-based Axel Springer S.E.
- Patients Retained Function Longer on AMX0035 Versus Placebo; Study Achieved Its Primary Outcome of a Difference on the Revised ALS Functional Rating Scale
- AMX0035 is the First Investigational Therapy to Demonstrate Statistically Significant Benefit on this Prespecified Primary Outcome in People with ALS Since Approved Therapy Edaravone
- AMX0035 Showed Numerical Benefits on Secondary Outcomes Including Measures of Muscle Strength, Breathing, and Hospitalizations
- AMX0035 Was Generally Well Tolerated with Similar Rates of Adverse Events Recorded in the AMX0035 and Placebo Groups
CAMBRIDGE, Mass.--(BUSINESS WIRE)--Amylyx Pharmaceuticals, Inc., a pharmaceutical company focused on developing new treatments for amyotrophic lateral sclerosis (ALS), Alzheimer’s disease and other neurodegenerative diseases, today announced the publication of results from the pivotal CENTAUR trial evaluating AMX0035 – an investigational neuroprotective therapy designed to reduce the death and dysfunction of motor neurons – in people with ALS in the New England Journal of Medicine (NEJM).
“CENTAUR met its prespecified primary outcome, showing a clinically meaningful and statistically significant treatment benefit on the Revised ALS Functional Rating Scale (ALSFRS-R), the most commonly used scale in clinics worldwide to measure function in ALS,” said Sabrina Paganoni, M.D., Ph.D., principal investigator of the CENTAUR trial, investigator at the Sean M. Healey & AMG Center for ALS at Mass General and Assistant Professor of PM&R at Harvard Medical School and Spaulding Rehabilitation Hospital. “These results represent a major milestone for the ALS community, and I am thrilled about the promise of this therapy for people with ALS.”
The CENTAUR trial of 137 individuals with ALS was conducted across 25 top medical centers in the U.S. through the Northeast ALS (NEALS) consortium. It demonstrated that treatment with AMX0035 was well tolerated and decreased the rate of decline in the ALSFRS-R compared to placebo in people with ALS.
“The data published today in the New England Journal of Medicine show that AMX0035 demonstrated a clinically meaningful benefit and a favorable safety profile for people living with ALS. This development is a breakthrough for the ALS community and we are working collaboratively and expeditiously with agencies worldwide to bring this potential new treatment option forward,” said Josh Cohen, Co-CEO, Chairman and Co-Founder at Amylyx.
“The data published today makes a clear and compelling case that AMX0035 should be made available to people with ALS as soon as possible,” said Calaneet Balas, President and CEO of The ALS Association. “We look forward to working with Amylyx, the FDA, and the entire community to help make that happen. We are grateful to all the Ice Bucket Challenge donors whose contributions helped make this trial possible.”
After 24 weeks, patients treated with AMX0035 scored on average 2.32 points higher on the ALSFRS-R than the placebo group (p=0.03) using the study’s primary prespecified analysis. A change from baseline analysis was also conducted and indicated that the AMX0035 group scored 2.92 points higher at the end of 24 week follow up (p=0.01).
- The ALSFRS-R is a 48-point questionnaire measuring daily functions such as the ability to walk, dress independently, self-feed, speak and breathe.
- Just a 1-2 point change in the ALSFRS-R score can indicate a significant reduction in a patient’s ability to function independently. The ALSFRS-R measures many different daily functions so point differences can manifest differently in different patients. Some examples of a two point change on this scale include the difference between an individual eating successfully with some difficulty vs needing a feeding tube, or walking with assistance versus not walking at all.
In line with the primary outcome, patients on AMX0035 also showed numerical benefits on secondary outcomes including measures of muscle strength, breathing and hospitalization frequency, although the study was not powered for secondary outcomes.
- Progression in lung function (percent predicted slow vital capacity) was numerically slower in patients taking AMX0035 (Least Squares Difference=5.11 points, p=0.08).
- Participants in the AMX0035 group were hospitalized numerically less often (Hazard Ratio = 0.54, p=0.09).
- Rate of decline in overall muscle strength (percent predicted ATLIS) was numerically slower in patients taking AMX0035 (Least Squares Difference=2.82 points, p=0.12). The effect of AMX0035 on progression was nominally statistically significant for the upper limbs measurements (Least Squares Difference=4.27 points, p=0.04).
- Nearly all participants (46 out of 48 patients in placebo (96%) vs 86 out of 89 patients in the AMX0035 group (97%)) reported one or more treatment-emergent adverse events (TEAEs) during the trial. Most were nonserious, did not lead to modification or interruption of study drug dosing, and were not considered related to the study.
- Overall, safety was comparable between the groups, with fewer serious adverse events in the active group as compared to the placebo group (9 out of 48 patients (19%) in placebo vs 11 out of 89 patients (12%) in the AMX0035 group).
- GI adverse events, which were generally characterized as mild by investigators, occurred more frequently in the active group in the first 3 weeks of the trial (28.1% vs 12.5% placebo) and returned to levels comparable to placebo thereafter.
Most CENTAUR participants (77%) were receiving an approved ALS therapy (riluzole, edaravone, or both) during and/or before trial entry. Sensitivity analyses accounting for the duration of treatment under riluzole, edaravone, or both confirmed that the treatment effect of AMX0035 was independent of background approved ALS therapies.
CENTAUR was the recipient of the ALS ACT grant, and is supported by The ALS Association, ALS Finding a Cure, a program of The Leandro P. Rizzuto Foundation, the Northeast ALS Consortium, Healey Center for ALS at Mass General, and was funded in part by the ALS Ice Bucket Challenge.
“I am so proud of the ALS community efforts that made this milestone possible,” said Dr. Merit Cudkowicz, M.D., Chief Medical Officer from ALS Finding a Cure®, Director of the Sean M. Healey & AMG Center for ALS, Chief of Neurology at Mass General, and the Julianne Dorn Professor of Neurology at Harvard Medical School. “The CENTAUR study was designed and run through NEALS, was supported by a partnership between The ALS Association and ALS Finding a Cure, and is a phenomenal example of what can happen when a community works closely together to accelerate ALS progress.”
AMX0035 Long-Term Survival and Extension Data, Future Plans
Participants who completed CENTAUR were given the option after the trial to enroll in an open-label extension study and receive AMX0035 long-term. 92% of eligible CENTAUR participants elected to enroll in the extension study. Interim data from the ongoing open-label extension study are being submitted to a peer-reviewed journal shortly and will be published in the coming months.
Long-term survival analysis for the patients in the AMX0035 and placebo groups has been conducted as well. These data will be submitted to a peer-reviewed journal in the near future.
“We are deeply grateful to all of the CENTAUR participants and our partners who have helped and continue to help develop this important therapy for those living with ALS,” said Justin Klee, Co-CEO and Co-Founder of Amylyx. “We also look forward in the coming months to sharing results from the CENTAUR open-label extension study and the long-term survival analysis, and we will continue to keep the community closely informed on next steps.”
CENTAUR was a 24-week, randomized, double-blind, placebo-controlled Phase 2/3 clinical trial that evaluated the safety and tolerability of AMX0035 and assessed the drug’s impact on disease progression as measured by the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) when compared to placebo. The trial also assessed the effects of AMX0035 on other measures that are critical to people with ALS, including muscle strength, lung vital capacity, and biomarkers of neuronal degeneration.
CENTAUR enrolled patients 18-80 years old with definite ALS and within 18 months of symptom onset. The trial did not restrict patients from receiving edaravone or riluzole. More information on the CENTAUR trial can be found at https://amylyx.com/trials/ or www.clinicaltrials.gov, NCT03127514.
About Amyotrophic Lateral Sclerosis (ALS)
ALS is a relentlessly progressive and fatal neurodegenerative disorder caused by motor neuron death in the brain and spinal cord. Motor neuron loss in ALS leads to deteriorating muscle function, the inability to move and speak, respiratory paralysis, and eventually death. The vast majority of patients with ALS (>90%) have sporadic disease, showing no clear family history. Approximately 6000 people are diagnosed with ALS in the United States every year with an approximately similar number of deaths every year.
AMX0035 is an investigational neuroprotective therapy designed to reduce neuronal death and dysfunction. AMX0035 targets endoplasmic reticulum and mitochondrial dependent neuronal degeneration pathways in ALS and other neurodegenerative diseases.
About Amylyx Pharmaceuticals
Amylyx Pharmaceuticals, Inc. is a pharmaceutical company working on developing a novel therapeutic for amyotrophic lateral sclerosis (ALS), Alzheimer’s disease and other neurodegenerative diseases. For more information, visit www.amylyx.com and follow us on LinkedIn and Twitter.
About The ALS Association
The ALS Association is the largest philanthropic funder of ALS research in the world. The Association funds global research collaborations, provides assistance for people with ALS and their families through its nationwide network of chapters and certified clinical care centers, and advocates for better public policies for people with ALS. The ALS Association builds hope and enhances quality of life while urgently searching for new treatments and a cure. For more information about The ALS Association, visit our website at www.alsa.org.
About ALS Finding a Cure
ALS Finding a Cure® is a research organization dedicated to being a game changer in discovering a cure for this fatal disease. Founded in 2014 by noted philanthropist and Conair Founder and Chairman, Leandro (Lee) Rizzuto, as a tribute to Christie Rizzuto, Lee’s daughter-in-law who was diagnosed with ALS in 2009 at the age of 41, and under the joint leadership of Denis Rizzuto and Peter N. Foss, ALS Finding a Cure® is focused on identifying the gaps in the scientific understanding of ALS that are preventing the development of a cure. The organization, a program of The Leandro P. Rizzuto Foundation, collaborates with a wide range of companies, ALS organizations, other disease non-profits, and ALS patients and families to ensure research efforts are non-duplicative, synergistic, and focused on the ultimate goal: getting to a cure. For more information about ALS Finding a Cure®, visit www.alsfindingacure.org.
About the Northeast ALS Consortium
The Northeast ALS Consortium (NEALS) is an international, independent, non-profit group of over 130 research sites around the world who collaboratively conduct clinical research in Amyotrophic Lateral Sclerosis (ALS) and other motor neuron diseases. The mission of NEALS is to translate scientific advances into new treatments for people with ALS and motor neuron disease as rapidly as possible. The NEALS network is governed by an Executive Committee and the Consortium research activities are advised by an experienced Scientific Advisory Board. Each Leadership team member brings a depth of experience and a unique perspective to the governance of NEALS. Through this leadership, active oversight is provided for ongoing operations along with new approaches to trial design evaluated and implemented.
Seasoned research vet joins company from Shoptalk, where she oversaw research and content
NEW YORK--(BUSINESS WIRE)--Insider Intelligence today announces that Zia Daniell Wigder is joining the company as senior vice president of content. Wigder, who recently left her position as chief global content officer at Shoptalk, will oversee research and content at Insider Intelligence, the recently named company composed of eMarketer and Business Insider Intelligence.
Wigder will manage a growing team of experienced researchers, analysts, forecasters, and editors – a group that has added 30 new members in 2020 alone. She will build upon the company’s renowned research in existing coverage areas, including advertising, marketing, media, and retail ecommerce, and lead further development of the financial services and digital health verticals. In addition, Wigder will work closely with eMarketer chief evangelist and co-founder Geoff Ramsey to spotlight the team’s work product to clients and the broader market.
“We couldn’t be happier that Zia is joining our growing team,” said Barbara Peng, president of Insider Intelligence. “Zia has the ideal background and experience to help us continue to make Insider Intelligence a must-read for any company looking to capitalize on the rapid-fire digital transformation impacting all industries.”
Wigder has more than 20 years of research and management experience. At Shoptalk, the world’s leading conference for retail and ecommerce, Wigder oversaw research and content. Wigder helped grow the company from a four-person startup into the fastest-growing retail conference in the world. She led the launch of the company’s original content division, which offers research on transformation in the retail sector based on data, case studies, and analysis.
Prior to Shoptalk, Wigder was vice president and research director at Forrester Research, where she managed a team of analysts covering commerce technologies, payments, and globalization.
"I'm thrilled to be joining Insider Intelligence and to be working with such a phenomenal team. Digital transformation has never been more critical to businesses, and both eMarketer and Business Insider Intelligence are at the forefront of helping companies make this transition. I look forward to bringing my broad experience – from venture-backed startups to established research companies – to this exciting new role."
Wigder will report to Peng and be based at the company’s world headquarters in New York City.
About Insider Intelligence
Formed in 2020 from the combination of eMarketer and Business Insider Intelligence (BII), Insider Intelligence aims to be the world’s leading research service focused on digital transformation. Insider Intelligence helps thousands of global industry leaders to better understand and plan for the critical trends and developments that are rapidly transforming their industries. Each year, Insider Intelligence produces nearly 300 reports, 7,000 charts, 1,500 newsletters, and 200 forecasts across a growing number of subjects including advertising & marketing, consumer demographics, social media, video, mobile, e-commerce & retail, telecoms & technology, financial services, and digital health industries. Insider Intelligence is owned by Berlin-based Axel Springer S.E.
Acquisition brings more than 400 labs and course materials onto Top Hat’s proven active learning courseware platform
Educators who adopt these titles on Top Hat’s all-in-one teaching platform have the flexibility to deliver engaging courses and motivate their students in any teaching environment, whether online or in-person, synchronous or asynchronous, at a time of great uncertainty on college campuses brought on by COVID-19
Following the recent acquisition of Nelson’s Canadian higher ed textbook business, Top Hat is bringing traditional publishers into the digital age
Top Hat’s platform enables educators to bring active learning to life for students inside and outside the classroom, with tools to live-stream lectures, present and edit slides, record lectures for later viewing, host live chats, poll and quiz students during class, assign homework, and deliver formative and summative assessments
More than 3 million students are enrolled in courses using Top Hat at 750 of the top 1,000 higher ed institutions in North America
TORONTO--(BUSINESS WIRE)--#collegeaffordability--Top Hat, the leading active learning platform for higher education, has acquired bluedoor, an independent press that specializes in educational content for the sciences in higher education. Details of the transaction were not disclosed. The acquisition includes more than 400 labs and course materials used by more than 500 authors. These materials are being converted into digital courseware on Top Hat’s platform and infused with interactive elements, enabling educators to bring active learning to life in both virtual and in-person classrooms.
bluedoor is a leading publisher of high-quality and flexible publications for science disciplines, and its content is used at more than 400 institutions in the United States. By converting bluedoor’s print-only content into interactive digital courseware, Top Hat is ensuring that educators who adopt these titles will now be able to engage and motivate students in any teaching environment, whether online or in-person, synchronous or asynchronous, at a time of great uncertainty in higher education brought on by the COVID-19 pandemic.
“bluedoor has a stellar reputation as an expert in educational content for the sciences,” said Mike Silagadze, founder and CEO, Top Hat. “Our partnership has evolved into a perfect fit for bluedoor to join Top Hat and strengthen our market position in the science disciplines. We are excited to work as one team to empower educators with the tools and content they need to easily and effectively encourage and support student outcomes.”
"At bluedoor, our focus has always been on empowering educators with flexible high-quality content," said Jon Earl, CEO, bluedoor. "By joining Top Hat and transforming our content into interactive digital courseware on its all-in-one platform, we can enable more educators to deliver their courses effectively and bring active learning to life for their students."
“By migrating my bluedoor lab manual onto Top Hat’s all-in-one learning platform, I’ve been able to create a fully interactive version that engages students both inside and outside the lab, with videos, GIFs, and assessments that provide in-depth feedback on correct and incorrect answers,” said Derek Weber, Professor Biology and Microbiology at Raritan Valley Community College, and author of Focusing on Health: Laboratory Exercises in Microbiology. “This instant feedback informs students of their strengths and weaknesses in real time, and enables instructors to identify and focus on those concepts that are most challenging to students. This feature is especially useful in an online or hybrid environment.”
As Higher Education Moves Online, Every Traditional Publisher Needs a Digital Distribution Strategy
In February, 2020, Top Hat announced it raised $55M USD in Series D financing to drive the shift from traditional textbooks to digital interactive course materials. The company is working with print publishers like Fountainhead Press to transform their print-only content into interactive digital courseware. At the same time, Top Hat is scaling its ability to empower professors with the technology and support to author, adopt, curate, and adapt course materials to create personalized and responsive learning experiences for students.
Prior to the acquisition of bluedoor, Top Hat acquired the Canadian domestic higher ed textbook business from Nelson, Canada’s largest educational publisher, to expand its broad portfolio of best-in-class content delivered through Top Hat’s active learning platform. The acquisition transformed the Canadian higher education publishing landscape and positioned Top Hat as a leading player in the industry.
“The COVID-19 crisis has laid bare the urgent need for a substantial overhaul of the traditional textbook industry,” said Silagadze. “Prior to the pandemic, we were already seeing the digital transformation of educational content. The events of the last few months have drastically accelerated that shift to help students overcome heightened challenges associated with the cost, accessibility, and relevance of print textbooks. And once the crisis has ended, both educators and students are not likely to forget the improved learning experience offered by interactive digital content. Every traditional publisher needs a digital distribution strategy—Top Hat makes that possible, with the added benefit of a proven active learning platform designed to improve student outcomes.”
Top Hat’s Active Learning Platform Enables Educators to Deliver Engaging and Effective Learning Experiences in the Fall and Beyond
Top Hat is the only all-in-one courseware platform that enables active learning—a proven student-centred teaching pedagogy that promotes deep understanding, critical thinking, and subject mastery—by encouraging students to engage with the content before, during, and after class, in both in-person and online courses. As the complete solution for any teaching scenario, Top Hat offers tools for in-person as well as synchronous and asynchronous online learning, while creating active engagement and connections with students inside and outside virtual class meetings.
To learn more about Top Hat:
About Top Hat
Top Hat is the only all-in-one courseware platform that enables active learning—a proven student-centred teaching pedagogy that promotes deep understanding, critical thinking, and subject mastery—with interactive content, tools, and activities. Millions of students at 750 leading North American colleges and universities use Top Hat to teach and engage with students before, during, and after class, in both in-person and online education.
Dianna Lai Read
Delivering national and team multimedia content across all SI platforms
The Hockey News’ team of award-winning journalists provides fans comprehensive coverage with breaking news, exclusive storytelling, insights, commentary, photos, videos, and podcasts.
"After 73 years in continuous print as the global source of hockey coverage, The Hockey News begins a new era as Sports Illustrated’s exclusive content partner, operating on Maven’s digital publishing platform,” says W. Graeme Roustan, chairman, owner and publisher of Roustan Media, which owns The Hockey News.
The Hockey News will continue to publish its own magazine, and the digital destination is now co-branded within SI.com, as the exclusive source of Hockey content for SI.com. The Hockey News’ premiere journalists will continue to produce award-winning national and local team-focused content they’re known the world over for and will now gain worldwide distribution through Sports Illustrated and Maven’s combined 150 million monthly users.
“SI’s partnership strategy is consistent with Maven’s focus, to partner with the most authentic and respected content leaders in each field and The Hockey News fits that description perfectly,” said SI CEO, Ross Levinsohn. “From award-winning journalists covering teams like Alabama and the Dallas Cowboys, to empowering the top experts in sports categories such as Fantasy and the NFL, Sports Illustrated combines its rich history of trusted storytelling and best in class journalists with best in class partners. The Hockey News brings an authentic voice, trusted storytelling and real time coverage to create a dynamic experience for sports fans.”
Graeme added: “This partnership brings together the best of hockey and sports for an all-around, multi-dimensional experience for hockey fans. All of us at The Hockey News are excited to provide multimedia hockey content to our millions of readers around the world."
“This partnership offers exclusive depth and breadth of hockey coverage to Sports Illustrated, providing strong, unbiased, timely and noteworthy news to our millions of readers around the world,” said Sports Illustrated Co-Editor-in-Chief Ryan Hunt.
The Hockey News is the newest member of Maven’s premium coalition of over 300 independent media brands. “Best in class” partners, such as Jim Cramer and TheStreet, History.com, Biography, Yoga Journal, Ski Magazine, Sports Illustrated, Glam, Maxim and top sports journalists around the world operate on Maven’s digital advertising, distribution and publishing platform.
About Sports Illustrated
Sports Illustrated is an award-winning media enterprise and cultural touchstone that captures moments in sports and turns them into history. Offering the most relevant and innovative content in real-time, SI is the authoritative voice of the sports world and the source that connects audiences to athletes and teams across every touchpoint spanning entertainment, editorial, and digital platforms to live events and brand extensions.
About The Hockey News
The Hockey News was founded by Ken McKenzie and Will Cote in 1947 and was later owned and sold in 2014 by Transcontinental Media to Quebecor. In 2018 W. Graeme Roustan formed Roustan Media and acquired The Hockey News from Quebecor.
Its Toronto based team of editors and network of reporters wherever hockey is played have been producing the very best publication of hockey industry content for the past 73 years.
Maven (maven.io) is a coalition of Mavens, from individual thought-leaders to world-leading independent publishers, operating on a shared digital publishing, monetization and distribution platform, unified under a single media brand. Sports Illustrated is operated by Maven as part of its coalition. Based in Seattle, Maven is publicly traded under the ticker symbol MVEN.
Media Inquiries: Greg Witter, Press@maven.io